Comparative Biochemistry and Toxicology

Publications:

Book chapters


  • TJ MacCormack, GG Goss, and RD Handy. Emerging threats: Engineered organic nanomaterials. In: Organic Chemical Toxicology of Fishes, volume 33 in the Fish Physiology series. Edited by K Tierney, AP Farrell, and CJ Brauner.Elsevier, London. 

Peer-reviewed papers

  1. Lamarre SG, MacCormack TJ, Bourloutski É, Callaghan NI, Pinto VD, Sykes AV, Driedzic WR. 2019. Interrelationship between contractility, protein synthesis and metabolism in mantle of juvenile cuttlefish (Sepia officinalis). Frontiers in Physiology 10:1051.
  2. Williams KJ, Cassidy AA, Verhille CE, Lamarre SG, MacCormack TJ. 2019. Diel cycling hypoxia enhances hypoxia-tolerance in rainbow trout (Oncorhynchus mykiss): Evidence of physiological and metabolic plasticity. J Exp Biol 222: jeb 206045. https://jeb.biologists.org/content/222/14/jeb206045.abstract
  3. Campbell LA, Gormley PT, Bennett JC, Murimboh JD, MacCormack TJ. 2019. Functionalized silver nanoparticles depress aerobic metabolism in the absence of overt toxicity in brackish water killifish, Fundulus heteroclitus. Aquat Toxicol 213: 105221. https://www.sciencedirect.com/science/article/pii/S0166445X19302899
  4. Callaghan NI, Capaz JC, Lamarre SG, Bourloutski É, Oliveira AR, MacCormack TJ, Driedzic WR, Sykes AV. 2019. Reversion to developmental pathways underlies rapid arm regeneration in juvenile European cuttlefish, Sepia officinalis (Linnaeus 1758). J Exp Zool B 332: 113-120. https://onlinelibrary.wiley.com/doi/full/10.1002/jez.b.22849
  5. Reid AJ, Carlson AK, Creed IF, Eliason EJ, Gell PA, Johnson PTJ, Kidd KA, MacCormack TJ, Olden JD, Ormerod SJ, Smol JP, Taylor WW, Tockner K, Vermaire JC, Dudgeon D, Cooke SJ. 2019. Emerging threats and persistent conservation challenges for freshwater biodiversity. Biol Rev 94: 849-873. https://onlinelibrary.wiley.com/doi/full/10.1111/brv.12480In the top 5% of research outputs scored by Altmetric and 3rd among all Biological Review papers, with shares to ~890,000 Twitter users. Made open access by the publisher as a result. Covered in ‘The Conversation’ https://theconversation.com/freshwater-wildlife-face-an-uncertain-future-108863 and subsequently reposted under creative commons license by the National Post https://nationalpost.com/pmn/news-pmn/freshwater-wildlife-face-an-uncertain-future
  6. Scott RS, Veinot AJ, Stack DL, Gormley PT, Khuong BN, Vogels CM, Masuda JD, Baerlocher FJ, MacCormack TJ, Westcott SA. 2018. Synthesis, reactivity and antimicrobial properties of boron-containing 4-ethyl-3-thiosemicarbazide derivatives. Can J Chem 96: 906-911. https://www.nrcresearchpress.com/doi/abs/10.1139/cjc-2018-0108
  7. Morash AJ, Neufeld C, MacCormack TJ, Currie S. 2018. The importance of incorporating natural thermal variation when evaluating physiological performance in wild species. Journal of Experimental Biology 221: jeb164673. https://jeb.biologists.org/content/221/14/jeb164673.abstract
  8. Braz-Mota S, Campos D, MacCormack TJ, Duarte R, Val AL, Almeida-Val VMF. 2018. Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Science of the Total Environment 630: 1168-1180. https://www.sciencedirect.com/science/article/pii/S0048969718306156
  9. NI Callaghan, KJ Williams, JC Bennett, TJ MacCormack. 2018. Nanoparticulate-specific effects of silver on teleost cardiac contractility. Environmental Pollution 237: 721-730. https://www.sciencedirect.com/science/article/pii/S0269749117334292
  10. H Xue, Y Wang, TJ MacCormack, T Lutes, C Rice, M. Davey, D Dugourd, TT Ilenchuk, JM Stewart. 2018. TRPV6 channel is elevated in human ovarian cancers and inhibition of it reduces tumour growth in a xenograft model in mice. Journal of Cancer 9: 3197-3207. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134823/
  11. MN Black, EF Henry, OA Adams, JC Bennett, TJ MacCormack. 2018. Environmentally-relevant concentrations of amine-functionalized copper nanoparticles exhibit different mechanisms of bioactivity in Fundulus heteroclitus in fresh and brackish water. Nanotoxicology 11: 1070-1085. https://www.tandfonline.com/doi/abs/10.1080/17435390.2017.1395097
  12. NI Callaghan, KJ Williams, TJ MacCormack. Cardioprotective mitochondrial binding by hexokinase I is induced by a hyperoxic acute thermal insult in the rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol B 224: 45-52. https://www.sciencedirect.com/science/article/pii/S1096495917301057
  13. EF Henry, TJ MacCormack. Taurine protects cardiac contractility in Fundulus heteroclitus by enhancing sarcoplasmic reticular Ca2+ cycling. J Comp Physiol B,  in press JCPB-D-17-00009. https://link.springer.com/article/10.1007%2Fs00360-017-1107-4
  14. JC Capaz, L Tunnah, TJ MacCormack, SG Lamarre, AV Sykes, WR Driedzic. 2017. Hypoxic induced decrease in oxygen consumption in cuttlefish (Sepia officinalis) is likely associated with decreases in protein synthesis and Na+/K+ ATPase. Frontiers in Physiology 8, 344.  https://www.frontiersin.org/articles/10.3389/fphys.2017.00344/full
  15. MJ Gallant, S LeBlanc, TJ MacCormack, S Currie. 2017. Physiological responses to short-term, environmentally realistic acute heat stress in Atlantic salmon, Salmo salar. FACETS 2: 330-341. http://facetsjournal.com/doi/10.1139/facets-2016-0053
  16. NI Callaghan, TJ MacCormack. Review: Ecophysiological perspectives on engineered nanomaterial toxicity in fish and crustaceans. Comp. Biochem. Physiol. C 193: 30-41.http://www.sciencedirect.com/science/article/pii/S1532045616301776
  17. PT Gormley, NI Callaghan, TJ MacCormack, CA Dieni. Assessment of the toxic potential of engineered metal oxide nanomaterials using an acellular model: citrated rat blood plasma. Toxicol. Mech. Meth. 26: 601-610 http://www.tandfonline.com/doi/abs/10.1080/15376516.2016.1218986?journalCode=itxm20
  18. NI Callaghan, L Tunnah, S Currie, TJ MacCormack. Metabolic adjustments to short-term diurnal temperature fluctuation in rainbow trout (Oncorhyncus mykiss). Physiol. Biochem. Zool. 89: 498-510. http://www.journals.uchicago.edu/doi/abs/10.1086/688680
  19. L Tunnah, S Currie, TJ MacCormack. Do prior diel thermal cycles influence the physiological response of Atlantic salmon (Salmo salar) to subsequent heat stress? Can. J. Fish. Aquat. Sci., in press. http://www.nrcresearchpress.com/doi/abs/10.1139/cjfas-2016-0157#.V3_iyzWYJL8
  20. NI Callaghan, GJ Allen, TE Robart, CA Dieni, TJ MacCormack. 2016. Zinc oxide nanoparticles trigger cardiorespiratory stress and reduce aerobic scope in the white sucker, Catostomus commersonii. NanoImpact 2: 29-37. http://www.sciencedirect.com/science/article/pii/S2452074816300088
  21. JR Treberg, SS Killen, TJ MacCormack, S Lamarre, E Enders. Measuring metabolic rate in fishes under field conditions: methods, proxies, and new perspectives. Comp. Physiol. Biochem. A, special issue on field physiology, 202: 10-22. http://www.sciencedirect.com/science/article/pii/S109564331630099X
  22. L Tunnah, SRC Mackellar, DA Barnett, TJ MacCormack, KM Stehfest, AJ Morash, JM Semmens, S Currie. Physiological responses to hypersalinity correlate with nursery ground usage in two inshore shark species (Mustelus antarcticus & Galeorhinus galeus). J. Exp. Biol. 219: 2028-2038. http://jeb.biologists.org/content/early/2016/05/06/jeb.139964
  23. B Speers-Roesch, NI Callaghan, TJ MacCormack, S Lamarre AV Sykes, WR Driedzic. Enzymatic capacities of metabolic fuel use in cuttlefish (Sepia officinalis) and responses to food deprivation: insight into the metabolic organization and starvation survival strategy of cephalopods. J. Comp. Physiol. B 186: 711-725.http://link.springer.com/article/10.1007/s00360-016-0991-3
  24. S Lamarre, TJ MacCormack, AV Sykes, JR Hall, B Speers-Roesch, NI Callaghan, WR Driedzic. Metabolic rate and rates of protein turnover in food deprived cuttlefish, Sepia officinalis (Linnaeus 1758). Am. J. Physiol. Reg. Integ. Comp. Physiol. 310: R1160-R1168. http://ajpregu.physiology.org/content/early/2016/04/01/ajpregu.00459.2015
  25. A Rundle, AB Robertson, AM Blay, KMA Butler, NI Callaghan, CA Dieni, TJ MacCormack. Cerium oxide nanoparticles exhibit minimal cardiac and cytotoxicity in the freshwater fish Catostomus commersonii. Comp Biochem Physiol C 181-182: 19-26. http://www.sciencedirect.com/science/article/pii/S1532045615001866
  26. TJ MacCormack, NI Callaghan, AV Sykes, WR Driedzic. 2015. Taurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis. J Comp Physiol B 186: 215-227. http://link.springer.com/article/10.1007/s00360-015-0946-0
  27. PT Gormley, BN Khuong, CM Dickie, AM Taweel, HL Blundon, JEJ Melanson, AF LeBlanc, TS Murphy, CG Tompkins, CM Vogels, A Decken, FJ Baerlocher, TJ MacCormack, SA Westcott. 2015. Synthesis, characterization and antimicrobial properties of lipophilic palladium complexes bearing iminopyridine ligands. Transition Metal Chemistry 40: 813-819. http://link.springer.com/article/10.1007/s11243-015-9977-3
  28. TJ MacCormack, JL Robinson, VMF Almeida-Val, AL Val, WR Driedzic. 2015. Acclimation to hypercarbia protects cardiac contractility and alters tissue carbohydrate metabolism in the Amazonian armored catfish Ptergoplichthys pardalis. Hydrobiologia, special issue on Amazon Aquatic Biota, 789: 91-106. http://link.springer.com/article/10.1007/s10750-015-2496-6
  29. RJ MacLellan, L Tunnah, D Barnett, PA Wright, TJ MacCormack, S Currie. 2015. Chaperone roles for TMAO and HSP70 during hyposmotic stress in spiny dogfish shark (Squalis acanthias). J Comp Physiol B 185: 729-740.http://link.springer.com/article/10.1007/s00360-015-0916-6
  30. RA Bessemer, KMA Butler, L Tunnah, NI Callaghan, A Rundle, S Currie, CA Dieni, TJ MacCormack. 2014. Cardiorespiratory toxicity of environmentally relevant zinc oxide nanoparticles in the freshwater fish Catestomus commersonii. Nanotoxicology 9: 861-870. http://informahealthcare.com/doi/abs/10.3109/17435390.2014.982737
  31. KJ Ong, TJ MacCormack, RJ Clark, JD Ede, VA Ortega, LC Felix, MKM Dang, G Ma, H Fenniri, JGC Veinot, GG Goss. 2014. Widespread nanoparticle-assay interference: Implications for nanotoxicity testing. PLOS ONE 9: e90650.http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090650
  32. CA Dieni, NI Callaghan, PT Gormley, KMA Butler, and TJ MacCormack. 2014. Physiological hepatic response to zinc oxide nanoparticle exposure in the white sucker, Catostomus commersonii. Comparative Biochemistry and Physiology C 162: 51-61. http://www.sciencedirect.com/science/article/pii/S1532045614000349
  33. KJ Ong, X Zhao, M Thistle, TJ MacCormack, RJ Clark, G Ma, Y Martinez-Rubi, B Simard, J Loo, JGC Veinot and GG Goss. 2013. Mechanistic insights into the effect of nanoparticles on zebrafish hatch. Nanotoxicology 8: 295-304. http://informahealthcare.com/doi/abs/10.3109/17435390.2013.778345
  34. CA Dieni, CJL Stone, ML Armstrong, NI Callaghan, and TJ MacCormack. 2014. Spherical gold nanoparticles impede the function of bovine serum albumin in vitro: a new consideration for studies in nanotoxicology. Journal of Nanomaterials and Molecular Nanotechnology 2:6.  http://www.scitechnol.com/ArchiveJNMN/currentissue-nanomaterials-molecular-nanotechnology.php
  35. A Schultz, KJ Ong, TJ MacCormack, G Ma, JGC Veinot, GG Goss. 2012. Silver nanoparticles inhibit sodium uptake in juvenile rainbow trout (Oncorhynchus mykiss). Environmental Science & Technology 46: 10295-10301. http://pubs.acs.org/doi/abs/10.1021/es3017717
  36. TJ MacCormack, R Clark, M Dang, J Kelly, JGC Veinot and GG Goss. 2012. Inhibition of enzyme activity by nanomaterials: potential mechanisms and implications for nanotoxicity testing. Nanotoxicology 6: 514-525. http://informahealthcare.com/doi/abs/10.3109/17435390.2011.587904
  37. JR Treberg, TJ MacCormack, JM Lewis, VMF Almeida-Val, AL Val and WR Driedzic. 2007. Intracellular glucose and binding of hexokinase and phosphofructokinase to particulate fractions increase under hypoxia in heart of the Amazonian armoured catfish (Liposarcus pardalis). Physiol. Biochem. Zool. 80: 542-550. http://www.jstor.org/stable/10.1086/520129
  38. TJ MacCormack and WR Driedzic. 2007. The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. Am. J. Physiol. 292: R1033-R1042. http://ajpregu.physiology.org/content/292/2/R1033
  39. TJ MacCormack, JM Lewis, VMF Almeida-Val, AL Val and WR Driedzic. 2006. Carbohydrate management, anaerobic metabolism, and adenosine levels in the armoured catfish, Liposarcus pardalis (Castelnau), during hypoxia. J. Exp. Zool. 305A: 363-375.  http://onlinelibrary.wiley.com/doi/10.1002/jez.a.274/abstract
  40. JR Hall, RC Richards, TJ MacCormack, KV Ewart and WR Driedzic. 2005. Cloning of GLUT3 cDNA from Atlantic cod (Gadus morhua) and expression of GLUT1 and GLUT3 in response to hypoxia. Biochimica et Biophysica Acta 1730: 245-252. http://www.sciencedirect.com/science/article/pii/S0167478105001855
  41. JR Hall, TJ MacCormack, CJ Barry and WR Driedzic. 2004. Sequence and expression of a constitutive, facilitated glucose transporter (GLUT1) in Atlantic cod (Gadus morhua). J. Exp. Biol. 207: 4697-4706. http://jeb.biologists.org/content/207/26/4697.long
  42. TJ MacCormack and WR Driedzic. 2004. Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. J. Exp. Biol. 207: 4157-4164. http://jeb.biologists.org/content/207/23/4157.long
  43. KA Clow, KJ Rodnick, TJ MacCormackand WR Driedzic. 2004. The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia. J. Exp. Biol. 207: 1865-1874. http://jeb.biologists.org/content/207/11/1865.long
  44. TJ MacCormack and ME DeMont. 2003. Regional differences in allometric growth in the lobster Homarus americanus. J. Crust. Biol. 23: 258-264. http://www.jstor.org/stable/1549630
  45. TJ MacCormack, RS McKinley, R Roubach, VMF Almeida-Val, AL Val and WR Driedzic. 2003. Changes in ventilation, metabolism, and behaviour, but not bradycardia, contribute to hypoxia survival in two species of Amazonian armoured catfish. Can. J. Zool. 81: 272-280. http://www.nrcresearchpress.com/doi/abs/10.1139/z03-003#.UnKIGhCFfSg
  46. TJ MacCormack, JR Treberg, VMF Almeida-Val, AL Val and WR Driedzic. 2003. Mitochondrial KATP channels and sarcoplasmic reticulum influence cardiac force development under anoxia in the Amazonian armored catfish Liposarcus pardalis. Comp. Biochem. Physiol. 134A: 441-448. http://www.sciencedirect.com/science/article/pii/S109564330200315X
  47. TJ MacCormack and WR Driedzic. 2002. Mitochondrial ATP-sensitive K+ channels (KATP) influence force development and anoxic contractility in flatfish (Limanda ferruginea) but not cod (Gadus morhua) heart. J. Exp. Biol. 205: 1411-1418.http://jeb.biologists.org/content/205/10/1411.long