Comparative Biochemistry and Toxicology


Book chapters

  • TJ MacCormack, GG Goss, and RD Handy. Emerging threats: Engineered organic nanomaterials. In: Organic Chemical Toxicology of Fishes, volume 33 in the Fish Physiology series. Edited by K Tierney, AP Farrell, and CJ Brauner.Elsevier, London. 
  • Dieni CA, MacCormack TJ. 2022. Cardiorespiratory toxicity of nanoparticles in aquatic environments. In:  Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial, and Aquatic Environments. MA Williams (Ed). John Wiley & Sons, Hoboken.

Peer-reviewed papers

  1. Dixon T-A, Rhyno E-L, El N, McGaw SP, Otley NA, Parker KS, Buldo EC, Pabody CM, Savoie M, Cockshutt A, Morash AJ, Lamarre SG, MacCormack TJ. 2023. Taurine depletion impairs cardiac function and affects tolerance to hypoxia and high temperatures in brook char (Salelinus fontinalis). J Exp Biol: jeb.245092
  2. McDougal RM, Cahill HF, Power ME, MacCormack TJ, Meli M-V, Rourke JL. 2022. Multiparametric cytotoxicity assessment: The effect of gold nanoparticle ligand functionalization on SKOV3 ovarian carcinoma cell death. Nanotoxicology 16: 355-374.
  3. Gates MA, Morash AJ, Lamarre SG, MacCormack TJ. 2021. Intracellular taurine deficiency impairs cardiac contractility in rainbow trout (Oncorhynchus mykiss) without affecting aerobic performance. J Comp Physiol B 192: 49-60.
  4. MacCormack TJ, Gormley PT, Khuong BN, Adams OA, Braz-Mota S, Duarte RM, Vogels CM, Tremblay L, Val AL, Almeida-Val VMF, Westcott SA. 2021. Boron oxide nanoparticles exhibit minor, species-specific acute toxicity to North-temperate and Amazonian freshwater fishes. Frontiers in Bioengineering and Biotechnology 9: 689933.
  5. Driedzic WR, MacCormack TJ, Lamarre SG. 2021. Contrasting strategies of hypoxic cardiac performance and metabolism in cichlids and armoured catfish. J Exp Zool A 335: 787-800.
  6. MacCormack TJ, Meli M-V, Ede JD, Ong KJ, Rourke JL, Dieni CA. 2021. Commentary: Revisiting nanoparticle-assay interference: there’s plenty of room at the bottom for misinterpretation. Comp Biochem Physiol B. 255: 110601.
  7. Morissette JD, Swart S, MacCormack TJ, Currie S, Morash AJ. 2021. Thermal variation near the thermal optimum does not affect the growth, metabolism or swimming performance in wild Atlantic salmon (Salmo salar). J Fish Biol 98: 1585-1589
  8. Malek M, Curtis I, MacCormack TJ, Meli M-V. 2020. Charged and neutral nanoparticles differentially affect the distribution of a transmembrane protein in a synthetic bio-membrane as a function of membrane pressure. ACS Applied Nanomaterials 3: 9276-9284
  9. Gormley PT, Geier SJ, Vogels CM, MacCormack TJ, Masuda JD, Westcott SA. 2020. Synthesis, characterization and antimicrobial activities of pentacyclic oxadiazadiborinanes. J Braz Chem Soc 31: 1541-1550.
  10. Ollerhead KM, Adams OA, Willett NJ, Gates MA, Bennett JC, Murimboh J, Morash AJ, Lamarre SG, MacCormack TJ. 2020. Polyvinylpyrolidone-functionalize silver nanoparticles do not affect aerobic performance or fractional rates of protein synthesis in rainbow trout (Oncorhynchus mykiss). Environ Pollut 260: 114044.
  11. Lamarre SG, MacCormack TJ, Bourloutski É, Callaghan NI, Pinto VD, Sykes AV, Driedzic WR. 2019. Interrelationship between contractility, protein synthesis and metabolism in mantle of juvenile cuttlefish (Sepia officinalis). Frontiers in Physiology 10:1051.
  12. Williams KJ, Cassidy AA, Verhille CE, Lamarre SG, MacCormack TJ. 2019. Diel cycling hypoxia enhances hypoxia-tolerance in rainbow trout (Oncorhynchus mykiss): Evidence of physiological and metabolic plasticity. J Exp Biol 222: jeb 206045.
  13. Campbell LA, Gormley PT, Bennett JC, Murimboh JD, MacCormack TJ. 2019. Functionalized silver nanoparticles depress aerobic metabolism in the absence of overt toxicity in brackish water killifish, Fundulus heteroclitus. Aquat Toxicol 213: 105221.
  14. Callaghan NI, Capaz JC, Lamarre SG, Bourloutski É, Oliveira AR, MacCormack TJ, Driedzic WR, Sykes AV. 2019. Reversion to developmental pathways underlies rapid arm regeneration in juvenile European cuttlefish, Sepia officinalis (Linnaeus 1758). J Exp Zool B 332: 113-120.
  15. Reid AJ, Carlson AK, Creed IF, Eliason EJ, Gell PA, Johnson PTJ, Kidd KA, MacCormack TJ, Olden JD, Ormerod SJ, Smol JP, Taylor WW, Tockner K, Vermaire JC, Dudgeon D, Cooke SJ. 2019. Emerging threats and persistent conservation challenges for freshwater biodiversity. Biol Rev 94: 849-873. the top 5% of research outputs scored by Altmetric and 3rd among all Biological Review papers, with shares to ~890,000 Twitter users. Made open access by the publisher as a result. Covered in ‘The Conversation’ and subsequently reposted under creative commons license by the National Post
  16. Scott RS, Veinot AJ, Stack DL, Gormley PT, Khuong BN, Vogels CM, Masuda JD, Baerlocher FJ, MacCormack TJ, Westcott SA. 2018. Synthesis, reactivity and antimicrobial properties of boron-containing 4-ethyl-3-thiosemicarbazide derivatives. Can J Chem 96: 906-911.
  17. Morash AJ, Neufeld C, MacCormack TJ, Currie S. 2018. The importance of incorporating natural thermal variation when evaluating physiological performance in wild species. Journal of Experimental Biology 221: jeb164673.
  18. Braz-Mota S, Campos D, MacCormack TJ, Duarte R, Val AL, Almeida-Val VMF. 2018. Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Science of the Total Environment 630: 1168-1180.
  19. NI Callaghan, KJ Williams, JC Bennett, TJ MacCormack. 2018. Nanoparticulate-specific effects of silver on teleost cardiac contractility. Environmental Pollution 237: 721-730.
  20. H Xue, Y Wang, TJ MacCormack, T Lutes, C Rice, M. Davey, D Dugourd, TT Ilenchuk, JM Stewart. 2018. TRPV6 channel is elevated in human ovarian cancers and inhibition of it reduces tumour growth in a xenograft model in mice. Journal of Cancer 9: 3197-3207.
  21. MN Black, EF Henry, OA Adams, JC Bennett, TJ MacCormack. 2018. Environmentally-relevant concentrations of amine-functionalized copper nanoparticles exhibit different mechanisms of bioactivity in Fundulus heteroclitus in fresh and brackish water. Nanotoxicology 11: 1070-1085.
  22. NI Callaghan, KJ Williams, TJ MacCormack. Cardioprotective mitochondrial binding by hexokinase I is induced by a hyperoxic acute thermal insult in the rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol B 224: 45-52.
  23. EF Henry, TJ MacCormack. Taurine protects cardiac contractility in Fundulus heteroclitus by enhancing sarcoplasmic reticular Ca2+ cycling. J Comp Physiol B,  in press JCPB-D-17-00009.
  24. JC Capaz, L Tunnah, TJ MacCormack, SG Lamarre, AV Sykes, WR Driedzic. 2017. Hypoxic induced decrease in oxygen consumption in cuttlefish (Sepia officinalis) is likely associated with decreases in protein synthesis and Na+/K+ ATPase. Frontiers in Physiology 8, 344.
  25. MJ Gallant, S LeBlanc, TJ MacCormack, S Currie. 2017. Physiological responses to short-term, environmentally realistic acute heat stress in Atlantic salmon, Salmo salar. FACETS 2: 330-341.
  26. NI Callaghan, TJ MacCormack. Review: Ecophysiological perspectives on engineered nanomaterial toxicity in fish and crustaceans. Comp. Biochem. Physiol. C 193: 30-41.
  27. PT Gormley, NI Callaghan, TJ MacCormack, CA Dieni. Assessment of the toxic potential of engineered metal oxide nanomaterials using an acellular model: citrated rat blood plasma. Toxicol. Mech. Meth. 26: 601-610
  28. NI Callaghan, L Tunnah, S Currie, TJ MacCormack. Metabolic adjustments to short-term diurnal temperature fluctuation in rainbow trout (Oncorhyncus mykiss). Physiol. Biochem. Zool. 89: 498-510.
  29. L Tunnah, S Currie, TJ MacCormack. Do prior diel thermal cycles influence the physiological response of Atlantic salmon (Salmo salar) to subsequent heat stress? Can. J. Fish. Aquat. Sci., in press.
  30. NI Callaghan, GJ Allen, TE Robart, CA Dieni, TJ MacCormack. 2016. Zinc oxide nanoparticles trigger cardiorespiratory stress and reduce aerobic scope in the white sucker, Catostomus commersonii. NanoImpact 2: 29-37.
  31. JR Treberg, SS Killen, TJ MacCormack, S Lamarre, E Enders. Measuring metabolic rate in fishes under field conditions: methods, proxies, and new perspectives. Comp. Physiol. Biochem. A, special issue on field physiology, 202: 10-22.
  32. L Tunnah, SRC Mackellar, DA Barnett, TJ MacCormack, KM Stehfest, AJ Morash, JM Semmens, S Currie. Physiological responses to hypersalinity correlate with nursery ground usage in two inshore shark species (Mustelus antarcticus & Galeorhinus galeus). J. Exp. Biol. 219: 2028-2038.
  33. B Speers-Roesch, NI Callaghan, TJ MacCormack, S Lamarre AV Sykes, WR Driedzic. Enzymatic capacities of metabolic fuel use in cuttlefish (Sepia officinalis) and responses to food deprivation: insight into the metabolic organization and starvation survival strategy of cephalopods. J. Comp. Physiol. B 186: 711-725.
  34. S Lamarre, TJ MacCormack, AV Sykes, JR Hall, B Speers-Roesch, NI Callaghan, WR Driedzic. Metabolic rate and rates of protein turnover in food deprived cuttlefish, Sepia officinalis (Linnaeus 1758). Am. J. Physiol. Reg. Integ. Comp. Physiol. 310: R1160-R1168.
  35. A Rundle, AB Robertson, AM Blay, KMA Butler, NI Callaghan, CA Dieni, TJ MacCormack. Cerium oxide nanoparticles exhibit minimal cardiac and cytotoxicity in the freshwater fish Catostomus commersonii. Comp Biochem Physiol C 181-182: 19-26.
  36. TJ MacCormack, NI Callaghan, AV Sykes, WR Driedzic. 2015. Taurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis. J Comp Physiol B 186: 215-227.
  37. PT Gormley, BN Khuong, CM Dickie, AM Taweel, HL Blundon, JEJ Melanson, AF LeBlanc, TS Murphy, CG Tompkins, CM Vogels, A Decken, FJ Baerlocher, TJ MacCormack, SA Westcott. 2015. Synthesis, characterization and antimicrobial properties of lipophilic palladium complexes bearing iminopyridine ligands. Transition Metal Chemistry 40: 813-819.
  38. TJ MacCormack, JL Robinson, VMF Almeida-Val, AL Val, WR Driedzic. 2015. Acclimation to hypercarbia protects cardiac contractility and alters tissue carbohydrate metabolism in the Amazonian armored catfish Ptergoplichthys pardalis. Hydrobiologia, special issue on Amazon Aquatic Biota, 789: 91-106.
  39. RJ MacLellan, L Tunnah, D Barnett, PA Wright, TJ MacCormack, S Currie. 2015. Chaperone roles for TMAO and HSP70 during hyposmotic stress in spiny dogfish shark (Squalis acanthias). J Comp Physiol B 185: 729-740.
  40. RA Bessemer, KMA Butler, L Tunnah, NI Callaghan, A Rundle, S Currie, CA Dieni, TJ MacCormack. 2014. Cardiorespiratory toxicity of environmentally relevant zinc oxide nanoparticles in the freshwater fish Catestomus commersonii. Nanotoxicology 9: 861-870.
  41. KJ Ong, TJ MacCormack, RJ Clark, JD Ede, VA Ortega, LC Felix, MKM Dang, G Ma, H Fenniri, JGC Veinot, GG Goss. 2014. Widespread nanoparticle-assay interference: Implications for nanotoxicity testing. PLOS ONE 9: e90650.
  42. CA Dieni, NI Callaghan, PT Gormley, KMA Butler, and TJ MacCormack. 2014. Physiological hepatic response to zinc oxide nanoparticle exposure in the white sucker, Catostomus commersonii. Comparative Biochemistry and Physiology C 162: 51-61.
  43. KJ Ong, X Zhao, M Thistle, TJ MacCormack, RJ Clark, G Ma, Y Martinez-Rubi, B Simard, J Loo, JGC Veinot and GG Goss. 2013. Mechanistic insights into the effect of nanoparticles on zebrafish hatch. Nanotoxicology 8: 295-304.
  44. CA Dieni, CJL Stone, ML Armstrong, NI Callaghan, and TJ MacCormack. 2014. Spherical gold nanoparticles impede the function of bovine serum albumin in vitro: a new consideration for studies in nanotoxicology. Journal of Nanomaterials and Molecular Nanotechnology 2:6.
  45. A Schultz, KJ Ong, TJ MacCormack, G Ma, JGC Veinot, GG Goss. 2012. Silver nanoparticles inhibit sodium uptake in juvenile rainbow trout (Oncorhynchus mykiss). Environmental Science & Technology 46: 10295-10301.
  46. TJ MacCormack, R Clark, M Dang, J Kelly, JGC Veinot and GG Goss. 2012. Inhibition of enzyme activity by nanomaterials: potential mechanisms and implications for nanotoxicity testing. Nanotoxicology 6: 514-525.
  47. JR Treberg, TJ MacCormack, JM Lewis, VMF Almeida-Val, AL Val and WR Driedzic. 2007. Intracellular glucose and binding of hexokinase and phosphofructokinase to particulate fractions increase under hypoxia in heart of the Amazonian armoured catfish (Liposarcus pardalis). Physiol. Biochem. Zool. 80: 542-550.
  48. TJ MacCormack and WR Driedzic. 2007. The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. Am. J. Physiol. 292: R1033-R1042.
  49. TJ MacCormack, JM Lewis, VMF Almeida-Val, AL Val and WR Driedzic. 2006. Carbohydrate management, anaerobic metabolism, and adenosine levels in the armoured catfish, Liposarcus pardalis (Castelnau), during hypoxia. J. Exp. Zool. 305A: 363-375.
  50. JR Hall, RC Richards, TJ MacCormack, KV Ewart and WR Driedzic. 2005. Cloning of GLUT3 cDNA from Atlantic cod (Gadus morhua) and expression of GLUT1 and GLUT3 in response to hypoxia. Biochimica et Biophysica Acta 1730: 245-252.
  51. JR Hall, TJ MacCormack, CJ Barry and WR Driedzic. 2004. Sequence and expression of a constitutive, facilitated glucose transporter (GLUT1) in Atlantic cod (Gadus morhua). J. Exp. Biol. 207: 4697-4706.
  52. TJ MacCormack and WR Driedzic. 2004. Cardiorespiratory and tissue adenosine responses to hypoxia and reoxygenation in the short-horned sculpin Myoxocephalus scorpius. J. Exp. Biol. 207: 4157-4164.
  53. KA Clow, KJ Rodnick, TJ MacCormackand WR Driedzic. 2004. The regulation and importance of glucose uptake in the isolated Atlantic cod heart: rate-limiting steps and effects of hypoxia. J. Exp. Biol. 207: 1865-1874.
  54. TJ MacCormack and ME DeMont. 2003. Regional differences in allometric growth in the lobster Homarus americanus. J. Crust. Biol. 23: 258-264.
  55. TJ MacCormack, RS McKinley, R Roubach, VMF Almeida-Val, AL Val and WR Driedzic. 2003. Changes in ventilation, metabolism, and behaviour, but not bradycardia, contribute to hypoxia survival in two species of Amazonian armoured catfish. Can. J. Zool. 81: 272-280.
  56. TJ MacCormack, JR Treberg, VMF Almeida-Val, AL Val and WR Driedzic. 2003. Mitochondrial KATP channels and sarcoplasmic reticulum influence cardiac force development under anoxia in the Amazonian armored catfish Liposarcus pardalis. Comp. Biochem. Physiol. 134A: 441-448.
  57. TJ MacCormack and WR Driedzic. 2002. Mitochondrial ATP-sensitive K+ channels (KATP) influence force development and anoxic contractility in flatfish (Limanda ferruginea) but not cod (Gadus morhua) heart. J. Exp. Biol. 205: 1411-1418.